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KMID : 1130620060020010051
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Journal of Clinical Neurology
2006 Volume.2 No. 1 p.51 ~ p.57
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Clinical Implications of Cardiac-MIBG SPECT in the Differentiation of Parkinsonian Syndromes
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Shin Dong-Hoon
Lee Phil-Hyu
Bang Oh-Young
Joo In-Soo
Huh Kyoon
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Abstract
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Background and Purpose: 123I cardiac meta-iodobenzylguanidine (MIBG), an analogue of norepinephrine, has been used to estimate myocardial sympathetic nerve function. We investigate whether cardiac-MIBG SPECT is clinically applicable in the differentiation of Parkinson’s disease (PD) from parkinsonian syndromes.
Methods: Cardiac-MIBG scintigraphy was performed in 27 controls, in 40 patients with PD and in 52 patients with other parkinsonian syndromes comprising 23 with multiple system atrophy (MSA), 26 with drug-induced parkinsonism (DIP), and 3 with corticobasal degeneration (CBD). The heart to mediastinum (H/M) uptake ratio was calculated for each subjects. Patients who either had medical conditions that confused the MIBG SPECT results or who took medications that interfere with MIBG accumulation were excluded from the study.
Results: Both early and delayed H/M ratios were in patients with PD significantly lower than in controls (early, 1.34±0.15 vs 1.79±0.19; delayed, 1.29±0.15 vs 2.06±0.29, p<0.001). In patients with PD, both early and delayed H/M ratios were significantly lower than those in patients with MSA (early, 1.68±0.23; delayed, 1.80±0.34, p<0.001), DIP (early, 1.83±0.24; delayed, 2.07±0.4, p<0.001), or CBD (early, 1.85±0.01; delayed, 1.99±0.19, p<0.001). Two patients with DIP, who were within the range of patients with PD, showed clinically similar courses of PD.
Conclusions: This study demonstrates that cardiac-MIBG is a clinically powerful tools to differentiate PD from other parkinsonian syndromes
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KEYWORD
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123I-MIBG SPECT, Parkinson’s disease, Multiple system strophy, Drug-induced parkinsonism
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